What can your cell age tell you about your overall health? A lot. Specifically, at Silene, we're looking at a part of the cell's DNA - the telomere - as an indicator of cell age.
The length of our telomeres decreases when our cells are replaced due to stress or damage. As a result, telomere length and decline is a great marker for "cell age", which is independent of our chronological age.
If you lead an unhealthy or stressful lifestyle, your cells age faster. Older cell age is correlated with a number of other risk factors for our health, including risk of death from cancers, heart disease, and even lifespan.
But just because we all age, doesn't mean we can't do so gracefully - your telomere length isn't "locked in" for life. By modifying your lifestyle and behaviors, you can slow down the shortening of your telomeres.
Telomeres are made up of repetitive DNA sequences and are roughly 11 kilobases (e.g. 11,000 "letters" of your DNA) at birth. Every time our DNA divides, we lose a little bit of DNA at the very ends, but since our DNA have telomeres, our genes are "protected" and instead, only our telomeres will shorten.
Although our telomeres will shorten inevitably due to the way our DNA replicates, if there is additional stress or damage to the DNA, more of the telomere will be lost. Below you will notice two telomere test results from two similarly-aged men.
"Active Ultimate Frisbee Coach"
An above average telomere score (10.43) in the 94th percentile.
"Stressed Startup Founder"
A below average telomere score (8.1) in the 49th percentile.
Although Uly is chronologically older than Alex, Uly’s telomere score indicates that he is biologically younger. Lifestyle changes to stress management, diet and exercise, and even sleep habits, can help reduce the underlying cause of DNA and cell damage, and consequently, slow the rate of telomere length decay.
Aging is inevitable. Our stem cells age with us and become less effective over time. Preserving your cells today is the only way of accessing your younger, healthier stem cells in the future. But just because you're aging doesn't mean you can't do so gracefully. By analyzing your cell age, you can also make informed decisions about your future health today. Combining preservation and cell age analysis is one of the best ways to prepare yourself for the future.
Purchase the StemFreeze (Premium or Concierge) service and schedule a blood draw at a partner location or at your home or office.
A trained phlebotomist draws your blood per the Silene Biotech protocol, collecting high quality stem cells in 90 seconds.
Your blood is sent to the FDA-registered lab, where your stem cells are concentrated, packaged, and frozen. A sample of your blood is reserved for telomere testing.
The length of the telomeres in your cells are measured using a state-of-the-art technique (quantitative polymerase chain reaction or qPCR). This method measures the average telomere length of the cells in your blood.
Our customers will have an opportunity to participate in a free consultation with award winning M.D. Dr. Myles Spar via teleconference. Together you will go through the results as well as any additional testing/insight that may need to be done to come up with a tailored plan for healthy aging. Results are typically available within 10-14 business days. HIPAA aware: Electronic delivery system is completely confidential and secure.
Telomeres are made up of repetitive DNA sequences, and are roughly 11 kilobases (e.g. 11,000 "letters" of your DNA) at birth. Every time our DNA divides, we lose a bit of DNA at the very ends. Since our DNA has these telomeres, our genes are "protected" and only our telomeres will shorten.
The cells that make up our bodies contain chromosomes which are made up of our DNA. In order to stay alive, those cells must replicate through division. In this process cells also lose a bit of DNA. To protect the important information in our DNA, every time the cell begins the replication process and divides, the telomere structures located at the end of our chromosomes protect the actual DNA by sacrificing a bit of their own structure instead.
Although our telomeres will shorten inevitably due to the way our DNA replicates, if there is additional stress or damage to the DNA, more of the telomere will be lost. Our telomere length will decrease over time (with each successive cell division), and there actually is a "critical minimum" telomere length where the cell cannot divide anymore without damaging the chromosome. This is called the "Hayflick Limit" and often causes cells to be unable to divide further (“cellular senescence”) which can contribute to a variety of diseases of aging.
After your draw, the blood is sent back to our lab for processing. A small portion of this blood is reserved for Cell Age Testing, which is a technique that involves amplifying DNA to measure the length of the telomeres.
Our customers will have an opportunity to participate in a free consultation with award winning M.D. Dr. Spar via teleconference. Together they will go through the results as well as any additional testing/insight that may need to be done to come up with a tailored plan for healthy aging.
Myles Spar, MD, MPH is board-certified in Internal Medicine. Dr. Spar graduated from the University of Michigan Medical School in 1993 and completed his residency in Internal Medicine at Tulane University, followed by a fellowship in Health Services Research and Masters in Public Health at UCLA. He then completed his fellowship in Integrative Medicine at the University of Arizona, under the guidance of his mentor, Andrew Weil, MD.
David Geffen School of Medicine, Dr. Spar teaches Integrative Medicine to medical students and residents. He also serves as a principal research investigator, on the care of patients using an integrative medicine approach. Dr. Spar has published and presented on topics related to integrative medicine, including men’s nutrition, chronic pain, and preventative medicine. His commitment to the benefits of Integrative Medicine is also reflected in his role as the President of Integrative Medicine Access (IMA). This non-profit organization focuses on providing affordable integrative medicine services to low income and medically underserved Americans. In 2013 Dr. Oz presented Dr. Spar with the prestigious Bravewell Leadership Award for Dr. Spar’s work in Integrative Medicine.