Important Information For Physicians

Personalized Regenerative Medicine for Your Patients

Silene Biotech's focus is the development and delivery of personalized biotechnology for all patients to optimize and improve our lives. We enjoy active collaborations with medical institutions and academic institutions to develop technology, as well as partnerships with forward thinking healthcare providers to access patients' cells and store them long term. By storing your patients' cells today, you establish the foundation of their personalized medicine platform and halt the cellular aging process, which can cause cells, even reprogrammed, to be less safe and effective for future use.

If you are interested in partnering with Silene Biotech to offer personalized regenerative medicine to your patients, please contact us at


PBMCs (CD34+ stem cells) have been shown to be an ideal cell for reprogramming into induced Pluripotent Stem Cells (iPSCs). By reprogramming PBMCs, we can then differentiate the resulting iPSCs into nearly every tissue type in the human body (see graphic below). Based on current research, generally cells must be reprogrammed into stem cells and then differentiated into the appropriate tissue type and then used for regeneration.

What We're Doing

Our base service involves a low-volume peripheral blood draw, concentration and collection of peripheral blood mononuclear cells (PBMCs), addition of cryopreservative to the cell solution, controlled rate freezing of the cells, and then long term storage of cells in liquid nitrogen. Current research shows that frozen cell samples can be stored for decades without loss of viability and without affecting the ability to reprogram cells. We are also actively collaborating on engineering patient tissues using stored samples in partnership with academic institutions.


Using pluripotent stem cells, regenerative treatments for diseases such as macular degeneration, heart disease, Parkinson's, Type 1 diabetes and spinal cord injury are in clinical trials around the world. However, using donor cells and tissues will require immunosupression. By having patients store their stem cells today, autologous cells and tissues can be engineered for regeneration without requiring immunosupression. This will be especially important for regeneration which can greatly improve quality of life but is non life-threatening, such as in cartilage repair, skin repair, and muscle repair.

Why the Type of Stem Cell Matters

Simple injection of undifferentiated stem cells for regenerative medicine, outside limited applications, has not shown to demonstrate long term regeneration and repair. In fact, it is this misunderstanding that ultimately led to the misuse of stem cells by the US Stem Cell clinic, causing 3 patients to go blind. The FDA is now proposing new regulations restricting the use of for-profit stem cell clinics to use unmanipulated stem cells in unproven treatments due to safety concerns.