Be one of the first to implement regenerative medicine in your practice.

Stem cell technology and regenerative medicine is coming. Be one of the first physicians to offer this technology to your patients and give them the opportunity at a longer and healthier life.

Silene Biotech offers 100% business integration with our service, as well as education in regenerative medicine and training on the stem cell collection. We also offer physicians and patients the opportunity to become involved in research collaborations, clinical trials for cutting edge therapies, and implementation of new technologies and services as they are developed.

Jump to:

Specific science
stem cell aging studies
Active clinical trials
sign up

The Specific Science and Biology of Silene Biotech


PBMCs (specifically CD34+ stem cells) have been shown to be an ideal cell for reprogramming into induced Pluripotent Stem Cells (iPSCs). By reprogramming PBMCs, we can then differentiate the resulting iPSCs into nearly every tissue type in the human body (see graphic below). Based on current research, for advanced regenerative technologies, cells must be reprogrammed into pluripotent stem cells and then differentiated into the appropriate tissue type and then used for regeneration.


What We're Doing

Our base service involves a low-volume peripheral blood draw, concentration and collection of peripheral blood mononuclear cells (PBMCs), addition of cryopreservative to the cell solution, controlled rate freezing of the cells, and then long term storage of cells in liquid nitrogen. Current research shows that frozen cell samples can be stored for decades without loss of viability and without affecting the ability to reprogram cells. We are also actively collaborating on engineering patient tissues using stored samples in partnership with academic institutions.


Using pluripotent stem cells, regenerative treatments for diseases such as macular degeneration, heart disease, Parkinson's, Type 1 diabetes and spinal cord injury are in clinical trials around the world. However, using donor cells and tissues will require immunosupression. By having patients store their stem cells today, autologous cells and tissues can be engineered for regeneration without requiring immunosupression. This will be especially important for regeneration which can greatly improve quality of life but is non life-threatening, such as in cartilage repair, skin repair, and muscle repair.

Why the Type of Stem Cell Matters

Simple injection of undifferentiated stem cells for regenerative medicine, outside limited applications, has not shown to demonstrate long term regeneration and repair. In fact, it is this misunderstanding that ultimately led to the misuse of stem cells by the US Stem Cell clinic, causing 3 patients to go blind. The FDA is now proposing new regulations restricting the use of for-profit stem cell clinics to use unmanipulated stem cells in unproven treatments due to safety concerns.

Stem Cell Aging Studies

Age and time affects the ability of stem cells to both self-renew as well as regenerate tissues. Additionally, mutations are implicated in diseases such as cancer. Below, two studies looked at the frequency of mutations in stem cell populations for blood, colon, small intestine and liver. All studies concluded that the mutation rate of stem cells increases significantly with age, starting during middle age and progressing until end of life.

Ongoing Clinical Trials

There are nearly 1,000 active or recruiting clinical trials investigating the use of stem cell-based therapies for diseases ranging from heart failure to joint pain. We've filtered the relevant trials via the FDA for you to review via the button below:


Sign Up and Join Silene

Name *